Abstract:

Ischemic cerebrovascular disease is one of ischemic diseases which is becoming a leading cause of morbidity and mortality in the whole world．Mesenchymal stem cells( MSCs) have been used to treat ischemic cerebrovascular diseases in animal models and clinical trials．Lots of publications demonstrated that MSCs therapy was safe and relieved symptoms of patients．However，many factors may influence therapeutic efficacy including transplantation route，time window，dose and source of MSCs．In this paper，all these factors as well as mechanisms of MSCs－based therapeutics for ischemic cerebrovascular and clinical trials safety are reviewed．It will provide help for further research and clinical treatment．

Key words: Mesenchymal stem cells( MSCs) , cell therapy, ischemic cerebrovascular diseases, cell transplantation, mechanism, transplantation route, time window for cell transplantation