University Science Park extends and strengthens university achievements through transformation, innovation and entrepreneurship, talent training and other functions in specific careers. Relying on universities, governments, enterprises and other resources to promote the construction and development of the university science park innovation cluster area, it is of great significance for effectively promoting the high-quality development of the regional economy and accelerating the realization of high-level science and technology self-reliance. Firstly, it discusses the theoretical basis of the university science park innovation cluster area; Secondly, on the level of theory and practice, it proposes and discusses the development path of the construction of the university science park innovation cluster area, including the development process of “1.0 stage: resource introduction/vision driven; 2.0 stage: resource accumulation/dividend driven; 3.0 stage: layout reconstruction/policy-driven”; Finally, it puts forward the development strategies for the construction of university science park innovation cluster area on the practical level.