Hypersonic weapon has the unique advantages of strong mobility, fast response speed, wide coverage and strong penetration ability. Its amazing combat effectiveness in the field of military application makes it gradually become a new strategic commanding point for the air and space competition of powerful countries and the focus of the strategic game of powerful countries. In order to pursue space safety and maintain strategic balance, countries are competing to carry out research on the construction of superb defense system, especially the construction of equipment system. Through extensive data collection, the situation and development trend of hypersonic weapon defense equipment system construction in the United States, Russia and other military powers are summarized. The hypersonic defense equipment system structure of the US is gradually clear, and it is accelerating the development of hypersonic defense technologies that support equipment capabilities. Russia is promoting the test and deployment of a new generation of aerospace defense systems, and has made significant progress in anti-hypersonic weapon systems. On this basis, through the analysis of the current situation and threats, suggestions and top-level thoughts on the construction of hypersonic weapon defense equipment system are putting forward from three aspects: building an early warning and detection network with three-dimensional coverage in the whole-area, avarious interception and strike network in the whole process, and a all-factor interconnection and efficient command and communication network.