WORLD SCI-TECH R&D ›› 2022, Vol. 44 ›› Issue (3): 354-370.doi: 10.16507/j.issn.1006-6055.2022.05.007

Special Issue: 科研仪器与设施

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Current Development of Domestic Proton Transfer Reaction Mass Spectrometry

ZOU Xue   ZHANG Qiangling   LIANG Qu   LU Yan   XIA Lei   LIU Yawei   HUANG Chaoqun SHEN Chengyin   CHU Yannan   

  1. Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China
  • Online:2022-06-25 Published:2022-07-04

Abstract:

Proton transfer reaction mass spectrometry (PTR-MS) is a rapid and sensitive technique for the detection of volatile organic compounds. Since its completion in 2008, domestic PTR-MS has reached the international advanced level in some technology and application fields. In this paper, we firstly introduced the principle of the instrument, and expounded the main influencing factors in the process of ionization, transmission and detection of the object to be measured. Then we showed the main products of domestic PTR-MS, including proton extraction reaction mass spectrometer (PER-MS), dipolar proton transfer reaction mass spectrometer (DP-PTR-MS), breath tester, spray inlet mass spectrometer (SI-PTR-MS), mobile proton transfer reaction mass spectrometer (M-PTR-MS), fast gas chromatography proton transfer reaction mass spectrometer (FGC-PTR-MS). Some products have been mass produced and sold. In terms of technological development, important progress has been made in the improvement of sensitivity and the preparation of multi reactive ions. Finally, we introduced the application of domestic PTR-MS in the fields of environment, medicine and safety, such as tracing the source of air pollution, excavating disease markers in human exhalation, rapid detection of explosives and soon. At the same time, the future development direction and application prospect of domestic PTR-MS were prospected.

Key words: Domestic, Proton Transfer Reaction Mass Spectrometer, Products, Application