›› 2017, Vol. 39 ›› Issue (3): 270-274.doi: 10.16507/j.issn.1006-6055.2017.03.019

• science and technology situation and trend • Previous Articles     Next Articles

Research Progress of Relationship between DEAD-box RNA Helicases Functions and Neoplasm

YE Hongji1,2 LI Shaolong1,2 AN Liping1,2,3 ZHOU Haiyu1   

  1. 1.Department of Orthopaedics, Second Hospital of Lanzhou University, Lanzhou 730030, China;2.Orthopaedics Key Laboratory of Gansu Province, Lanzhou 730030, China;3.The People’s Hospital of Dingxi, Dingxi 743000, China
  • Received:2016-10-14 Revised:2016-11-25 Online:2017-06-25 Published:2017-06-23

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Abstract:

DEAD-box RNA helicases (DDX) are a member of RNA helicases superfamily, they utilize energy derived from nucleotide triphosphate (NTP) hydrolysis and function as molecular complexes by interacting with other proteins in cell. DDX are implicated in  remolding ribonucleoprotein complexes, RNA or DNA and in this manner affect the output and poly morphism of RNA. Nowadays, with an increasing number of researches, it has been identified that DDX are playing critical roles in tumorigenesis and tumor progression, their expression levels are related with tumor growth, metastasis and prognosis, besides, DDX are suggested to have both pro and antiproliferative roles in cancer. In this review, the research progress of relationship between DDX functions and neoplasm are reviewed to discuss the mechanism of DDX in tumor initiation, development and the significance of DDX in tumor prognosis and therapeutic.

Key words: RNA helicase, DEAD-box RNA helicase, neoplasm

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