Under the background of Belt and Road, the cross-border e-commerce industry has become an important part of China's economic growth, driven by the rapid development of information technology and modern logistics. By studying the fusion mechanism, this paper explores the innovative blockchain application in the cross-border e-commerce for industrial development and transformation promotion. Firstly, the technological logic of the integration of blockchain technology and cross-border e-commerce is analyzed from the core technology and distinct advantages of blockchain. The three-dimensional integration framework is developed from the organizational, technical, and functional perspectives. Secondly, the blockchain-driven information platform is constructed to link technical implementation and industrial applications. The multi-layer integration structure integrating blockchain with cross-border e-commerce is designed to portray the transaction process of cross-border e-commerce. Lastly, the application prospects of the deeper integration of blockchain technology and cross-border e-commerce are investigated. Suggestions are put forward from various aspects of e-commerce operation mode, technology implementing development, industry-university-research integration, stimulating R&D and innovation, enhancing relevant laws, and establishing a solid regulatory mechanism, so as to provide guidance on integration achievement of blockchain technology and cross-border e-commerce.