Abstract:

Ulcerative Colitis( UC) is a chronic non －specific intestinal inflammatory disease whose pathogenesis is not very clear．It is currently considered that Th17 /Treg cells imbalance involved in the development of UC．In this paper，the function and research progress of Th17 /Treg cells and their related cytokines in UC are reviewed．It is found that whether the increase of Th17 cells or the decrease of Treg cells can lead to the occurrence of UC．Th17 cells play a dual role in the pathogenesis of UC，which can protect the intestinal mucosa by maintaining the balance of the immune microenvironment，and also can aggravate intestinal inflammatory reaction，but mainly play a role in promoting inflammation．However，Treg cells inhibit intestinal inflammation cascade and amplification reaction mainly through the secretion and regulation of IL-10，TGF-β．

Key words: ulcerative colitis, regulatory T cells, T helper 17 cells, cytokines