关键词: 哌嗪, 抗菌, 抗真菌, 抗糖尿病, 抗阿尔茨海默病, 镇痛, 脂肪酰胺水解酶抑制剂

Abstract:

Piperazine ring is an important class of heterocyclic nitrogen which is widely used in structural modification of drugs．The introduction of piperazine ring into compounds，which are targeting DNA topoisomerase，lansterol 14α-demethylase，(1，3) -β-D-glucan synthase，11β-hydroxy steroid dehydrogenase 1，glucokinase，beta-site APP cleaving enzyme 1 and fatty acid amide hydrolase，not only could enhance their efficacy and improve pharmacokinetic properties，but also could be easy to be modified to constitute a hybrid with multi pharmacological targets． These compounds have shown a wide range of biological activities and could be used for the treatment of bacterial infection，fungal infection，type 2 diabetes，Alzheimer's disease and pain，which have great development value．Therefore，the recent advances of the piperazine-containing compounds as antibacterial agents，antifungal agents，anti-diabetes agents，anti-Alzheimer's disease agents and anodyne were described，and their structure-activity relationship were also reviewed．

Key words: piperazine, antibacterial, antifungal, anti-diabetes, anti-Alzheimer's disease, analgesia, FAAH inhibitor